Oncology

Understanding Carcinogenesis

ID: 08021509

Understanding Carcinogenesis

Understanding Carcinogenesis
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Course Length:

  • 44 topics
  • 68 minutes of seat time

Language:

  • English

Course Features:

  • Audio narration
  • Animations
  • Progress checks
  • Pop quizzes
  • Final assessment

Target Audience:

  • Medical professionals
  • Medical students
  • Pharmaceutical representatives
  • Nurses

Description:

Cancer is a disease that originates from a single cell that grows out of control. Cancer cells can bypass the most basic cellular checks and balances because of abnormal genes. These cells exploit cellular mechanisms that are normally strictly regulated to keep an organism in balance. This learning program is designed to introduce you to the basic principles of cancer biology, with a focus on the multistage process of cancer. The program begins with an overview of the nature of cancer, including its definition and etiology, followed by in-depth presentations on the molecular and cellular biology of cancer. You will learn about the origins of cancer in normal tissue and its progressive nature in the body. You will also learn about the body’s defenses and the repair mechanisms that normally prevent cancer development.

Upon completion of this learning program, you will be able to:

  • Provide a broad definition of cancer.
  • Identify the 2 main gene categories involved in cancer progression.
  • Discuss the role of mutations in oncogenesis and list the primary causes of mutations.
  • Describe the cancer hallmarks that give rise to tumor growth.
  • Explain the cellular mechanisms that allow cancer invasion and metastasis.
  1. GETTING STARTED
    1. Sound Check
    2. Disclaimer
    3. Welcome
    4. Navigation Instructions
  2. STAYING FOCUSED
    1. Introduction
    2. Learning Objectives
  3. THE NATURE OF CANCER
    1. Overview
    2. Definition of Cancer
    3. Pop Quiz
    4. Etiology of Cancer at a Glance
      • Popup: 1890 to 1910
      • Popup: 1930 to 1950
      • Popup: 1950 to 1970
      • Popup: 1970 to 1990
      • Popup: 1990 to 2010
      • Popup: 2010 to 2020
    5. Multistep Oncogenesis
      • Popup: Initiation
      • Popup: Promotion
      • Popup: Progression
    6. Progress Check
  4. MOLECULAR BIOLOGY OF CANCER
    1. Overview
    2. Oncogenes
      • Side Note: Digging Deeper – List of Common Oncogenes
    3. Tumor Suppressor Genes
      • Side Note: Digging Deeper – List of Common TSGs
    4. Pop Quiz
    5. Mechanisms of Oncogene Activation and TSG Inactivation
      1. Overview
      2. DNA Repair and Genetic Instability
        • Popup: Base Excision Repair
        • Popup: Nucleotide Excision Repair
        • Popup: Nonhomologous End-Joining
        • Popup: Homologous Recombination
      3. Pop Quiz
      4. Mutations
        • Popup: Point Mutations
        • Popup: Translocations
        • Popup: Amplifications and Deletions
        • Popup: Whole Chromosome Gain or Loss
      5. Epigenetics
      6. Progress Check
      7. Chemical Carcinogenesis
      8. Radiation
        • Popup: UV Light
        • Popup: Ionizing Radiation
      9. Pop Quiz
      10. Oncoviruses
      11. Inflammation
      12. Pop Quiz
      13. Hereditary Factors
    6. Neoplastic Transformation
  5. CELLULAR BIOLOGY OF CANCER
    1. Overview
    2. Sustaining Proliferative Signaling
    3. Evading Growth Suppressors
    4. Resisting Apoptosis
    5. Pop Quiz
    6. Enabling Replicative Immortality
    7. Deregulating Cellular Energetics
      • Side Note: Digging Deeper – The Warburg Effect
    8. Progress Check
  6. CANCER INVASION AND METASTASIS
    1. Overview
    2. Inducing Angiogenesis
      1. What Is Angiogenesis?
      2. Neoplastic Angiogenesis
    3. Pop Quiz
    4. Activating Invasion and Metastasis
      1. Overview
      2. Epithelial-Mesenchymal Transition
      3. Extravasation and Intravasation
      4. Colonization
        • Side Note: Digging Deeper – Main Sites of Metastasis
    5. Progress Check
    6. Avoiding Immune Destruction
    7. Pop Quiz
  7. TEST YOUR ACQUIRED KNOWLEDGE
    1. Summary
    2. Final assessment
  8. END OF PROGRAM
  9. GLOSSARY
  10. REFERENCES



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